Thermodynamic consequences of molecular crowding in information growth during pre biotic evolution

*Lecturer & Head (Biochemistry), Institute of Public Health & Hygiene, RZ-A-44, Mahipalpur, New Delhi-110038, India ** Professor, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi-110067, India *Email of Corresponding Author: [email protected] Abstract The work presented in this paper essentially focuses at providing a scientific theory to explain the growth of information bearing molecules (size and informatio0n contents) without the need of any enzymatic system. It infers the footprints of molecular evolution in the cell interior for a property common to all life forms. It is deducted that molecular crowding is a vital cellular trait common to the all types of cells (primitive or highly evolved). It is argued that this trait is pervasive and must have been incorporated at some stage as a common vital feature of life. If this feature has central importance it must have been part of the pre-biotic information growth of information bearing molecules. The thermodynamic consequences of molecular crowding on the growth of RNA (50100bp long) in the absence of enzyme system were calculated.